Dapoxetine: Uses, Interactions, Mechanism of Action DrugBank Online

With the exception of fluvoxamine, most SSRIs have been shown to clinically delay ejaculatory time (Table 1) (75). Daily use of SSRIs increases geometric mean IELT by 2.6 to 13.2 fold (75). The metabolites of dapoxetine include dapoxetine-N-oxide, desmethyldapoxetine and didesmethyldapoxetine. At 24 hours, plasma dapoxetine concentrations drop to 3.5% and 3.9% of peak concentrations for 30 and 60 mg doses, respectively (80).

Animal studies

When your body doesn’t perform the way you’d like, it’s easy to become discouraged. One challenge many face is erectile dysfunction (ED), which makes it difficult to achieve or maintain an erection. An estimated 30 million Americans suffer from ED, but many fail to seek treatment due to time constraints, stigma, and privacy concerns. Compare dapoxetine prices available at Canadian andinternational online pharmacies with local U.S. pharmacy coupon prices. The lowest price on PharmacyChecker.com for dapoxetine 30 mg is $1.86 per tablet for 24 tablets at PharmacyChecker-accredited online pharmacies.

Medical Professionals

The company prides itself on making the process of obtaining your prescription as seamless as possible. You won’t need to wait in any lines; the app automatically tracks refills; and you can text, call, email, or chat with your pharmacist anytime. Plus, Capsule handles all the coordination between your doctor and your insurance company, so you won’t need to deal with them directly. Shipping is around $10 per package (not per drug), although additional charges may be applicable for overweight packages. Up to a three-month supply is deliverable at one time, all sales are final, and refunds are not allowed.

Your provider can prescribe medications like brand name and generic Cialis, Viagra, Stendra, or Levitra if necessary. The company also offers 24/7 per-visit urgent care or an unlimited membership option, but ED requires a primary care appointment for long-term treatment and regular Cytomel muscle building refills. You can manage appointments, medications, and chats from your K Health dashboard. Obtaining a prescription through Hims is straightforward—simply fill out the questionnaire on the website with your medical history and any current medications or supplements you’re taking.

• Topical local anesthetics such as lidocaine and/or prilocaine are the oldest drugs used for PE treatment.
• The online pharmacy industry has exploded in the last several years, and your head may be spinning from all the choices.
• These drugs also have to be specially labeled, so many online pharmacy companies have already elected not to deliver them.

The pharmacy has a bonus referral program, too, earning you around $25 in credit for each referral and saving your friend about $25 on their first order too. You can get $25 off of your medications when you refer others to Canada-based DoctorSolve, which dispenses prescription, non-prescription, and pet medications. According to the FDA, generic medications contain the same active ingredients as brand names, meaning there’s no difference in effectiveness or safety.

Another potential medical treatment option for PE is the phosphodiesterase type 5 (PDE-5) inhibitors. Theoretically, a man trying to decrease his level of excitation to prevent PE may lead to ED, and conversely a man trying to excite himself to remedy his ED may experience PE. In theory, these are two sides of the same coin and may be superimposed upon each other (49).

Online pharmacy and dermatology telehealth company, Apostrophe cuts the impatience out of patient care. To use Lemonaid Health, you must book a consultation with one of its providers. The good news is that an appointment costs just $25, regardless of whether you have insurance. In most states, the consultation can be done via a questionnaire asking about your current health and medical history. Still, in some states (like Arkansas and New Mexico) a video consultation is required.

Fortunately, telemedicine has revolutionized the way people access healthcare—including the treatment of ED. With online ED prescriptions, you can easily access FDA-approved medications from the convenience of your smartphone or computer—and the medications can be shipped discreetly right to your door. You can often consult a board-certified provider and secure a  prescription in as little as 15 minutes. That said, it’s not always easy to find reputable providers so to help, we evaluated 17 telehealth companies that prescribe ED medication online. These drugs aren’t approved by the Food and Drug Administration to treat premature ejaculation, but some are used for this purpose. They include antidepressants, pain relievers and drugs for erectile dysfunction.

One-time deliveries or subscription options with monthly or quarterly deliveries are available. You’ll also have access to an online portal to ask questions, report side effects, and manage delivery and payments. If your medical needs change or the medication isn’t working in the way you hoped, your provider can adjust your treatment plan or request a complimentary follow-up to review other options.

Dapoxetine was rapidly absorbed, with mean maximal plasma concentrations of 297 and 498 ng/mL at 1.01 and 1.27 hours after single doses of dapoxetine 30 and 60 mg, respectively (Table 1). Elimination of dapoxetine was rapid and biphasic, with an initial half-life of 1.31 and 1.42 hours, and a terminal half-life of 18.7 and 21.9 hours following single doses of dapoxetine 30 and 60 mg, respectively. The pharmacokinetics of dapoxetine and its metabolites were not affected by repeated daily dosing and steady state plasma concentrations were reached within 4 days, with only modest accumulation of dapoxetine (approximately 1.5-fold) (Fig. 2B). Because of its rapid action and short half-life, the on-demand use of dapoxetine makes it a popular alternative for treating PE (94-97).